Kate Matthews

This article has no abstract so we have provided the first paragraph of the full text.

Genetic anticipation is a phenomenon whereby hereditary disease onset occurs at an earlier age in successive generations. Understanding genetic anticipation in familial pancreatic cancer could provide insight into the genes responsible for this disease, improve linkage analysis and prediction of disease occurrence. Studies on anticipation in familial pancreatic cancer have been small and subject to bias; therefore, McFaul et al. used a large study population of at-risk individuals, and standard and novel analytical methods that reduce biases, to investigate whether anticipation occurs in this disease.

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